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pdf Angelman Syndrome: Finding the Lost Arc Populair
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Tai HC 2010 Cell 140-608.pdf
Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome. Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternallyinherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3Asubstrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight intosynaptic defects that may underlie the cognitive deficits in Angelman syndrome.
Hwan-Ching Tai and Erin M. Schuman
Cell 140, March 5, 2010 ©2010 Elsevier Inc.
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